
AOD-9604
hGH fragment 176-191
The file here is mostly preclinical work plus clinic and community practice, not registrational trials.
Phase II human trials largely failed their primary endpoint. Worth knowing.
General profile
- Class
- Fat loss and metabolic
- Evidence
- Early or preclinical only
- Studied dose range
- 300 mcg
- Frequency in protocols
- Daily, 5 on / 2 off
- Route
- Subcutaneous
- Half life
- ~2 hours
- Reconstitution
- 2 mL bacteriostatic water per 5 mg vial
- Storage
- Refrigerated, ~30 days
Timing and cycling in the literature
Usually dosed in the morning window, fasted
Daily, five days on and two off in most protocols
Studied in a fasted morning window before food. Note the phase II human trials largely missed their primary endpoint.
Reported cycle: 12 weeks on, 4 weeks off
The phase II trials dosed daily for 12 weeks. Worth remembering they largely missed their primary endpoint.
Watch for: Little in the safety record, which is the one genuinely reassuring thing about it.
What it conflicts with
Three separate questions, kept separate. A hard stop means the mechanisms must not run together at all and timing does not fix it. A syringe rule means the same day is fine but one barrel is not. Redundancy is not dangerous, it is paying twice to hit one target.
- Separate syringesTiming
AOD-9604 + GLP-1 analogs
Separate by at least a day
Overlapping metabolic and appetite effects with heavily overlapping gastrointestinal side effects. Running them together makes it impossible to attribute nausea to either compound, which is exactly what you need to be able to do when titrating.
- Pick oneRedundant, pick one
AOD-9604 + Lipo-C
Same target hit twice
Overlapping fat-metabolism framing with no additive evidence.
Most syringe compatibility claims here are practice and expert consensus, not peer reviewed mixing studies. A clear liquid after mixing does not prove the compounds are still active, and cloudiness, particles or gelling means discard. Active cancer, pregnancy, major cardiac care and heavy immunosuppression override every stack preference on this page.
See how AOD-9604 fits your week
The injection scheduler spaces doses using the clinical timing data, flags the pairs above before you draw them, and tells you why.
Model this in the injection schedulerThe studies
Human trials: No completed human efficacy trial that establishes a dose for the use people are chasing.
Open questions: Treat published dosing as observed practice, not a validated protocol.
Published papers
Indexed from Europe PMC and refreshed weekly. Each link opens the paper itself.
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance
Sports Med · 2026 · Review. Mendias CL, Awan TM.
- Annual Banned-Substance Review 18th Edition-Analytical Approaches in Human Sports Drug Testing 2024/2025
Drug Test Anal · 2026 · Review. Thevis M, Kuuranne T, Geyer H.
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
J Am Acad Orthop Surg Glob Res Rev · 2026 · Review. Rahman OF, Lee SJ, Seeds WA.
- Annual Banned-Substance Review 17th Edition-Analytical Approaches in Human Sports Drug Testing 2023/2024
Drug Test Anal · 2025 · Review. Thevis M, Kuuranne T, Geyer H.
- Illegal and falsified medicines self-administrated in not approved post-cycle therapy after the cessation of anabolic-androgenic steroids - qualitative analysis
Front Chem · 2025. Blazewicz A, Poplawska M, Daniszewska B, Piorunska K, Karynski M.
- Peptides for Targeting Chondrogenic Induction and Cartilage Regeneration in Osteoarthritis
Cartilage · 2024. Liao HJ, Chen HT, Chang CH.
- Human Growth Hormone Fragment 176-191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells
Drug Des Devel Ther · 2022. Habibullah MM, Mohan S, Syed NK, Makeen HA, Jamal QMS, Alothaid H, Bantun F, Alhazmi A, Hakamy A, Kaabi YA, Samlan G, Lohani M, Thangavel N, Al-Kasim MA.
- Human sports drug testing by mass spectrometry
Mass Spectrom Rev · 2017 · Review. Schänzer W, Thevis M.
- Simplifying and expanding the screening for peptides <2 kDa by direct urine injection, liquid chromatography, and ion mobility mass spectrometry
J Sep Sci · 2016. Thomas A, Görgens C, Guddat S, Thieme D, Dellanna F, Schänzer W, Thevis M.
- Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model
Ann Clin Lab Sci · 2015. Kwon DR, Park GY.
Search the full literature
- PubMed: all indexed papers
Every indexed paper, newest first. Filter to Clinical Trial or Review in the sidebar.
- PubMed: human clinical trials only
The honest test of an evidence claim. An empty result is itself an answer.
- ClinicalTrials.gov registrations
Registered, ongoing and completed trials, including ones that never published.
- Europe PMC full text
Often surfaces open-access full text that PubMed only abstracts.