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Research vial labelled AICAR, a Mitochondrial and metabolic peptide studied in preclinical and clinical literature

AICAR

The file here is mostly preclinical work plus clinic and community practice, not registrational trials.

An AMPK activator best known as an exercise mimetic in rodents. Human translation is weak and the effective amounts are impractical.

General profile

Class
Mitochondrial and metabolic
Evidence
Early or preclinical only
Studied dose range
Study amounts are large and route dependent
Frequency in protocols
Per study design
Route
Subcutaneous or intravenous in studies
Half life
Minutes
Reconstitution
5 mL bacteriostatic water per 50 mg vial
Storage
Refrigerated, ~30 days

Timing and cycling in the literature

Usually dosed in the morning window, fasted

Two to three times weekly

Studied as an exercise mimetic on AMPK signalling, so protocols use the fasted pre-activity window.

Reported cycle: 4 weeks on, 4 weeks off

Rodent exercise-mimetic protocols run in short blocks. Human translation is weak enough that longer is guesswork.

Watch for: Heart rate and exercise tolerance. The effective amounts in animals are impractically large.

What it conflicts with

Three separate questions, kept separate. A hard stop means the mechanisms must not run together at all and timing does not fix it. A syringe rule means the same day is fine but one barrel is not. Redundancy is not dangerous, it is paying twice to hit one target.

No named pair conflicts are on file for this compound. That is missing data, not clearance: with no compatibility data the default is separate syringes, and you still introduce one new compound at a time.

Most syringe compatibility claims here are practice and expert consensus, not peer reviewed mixing studies. A clear liquid after mixing does not prove the compounds are still active, and cloudiness, particles or gelling means discard. Active cancer, pregnancy, major cardiac care and heavy immunosuppression override every stack preference on this page.

See how AICAR fits your week

The injection scheduler spaces doses using the clinical timing data, flags the pairs above before you draw them, and tells you why.

Model this in the injection scheduler

The studies

Human trials: No completed human efficacy trial that establishes a dose for the use people are chasing.

Open questions: Treat published dosing as observed practice, not a validated protocol.

Published papers

Indexed from Europe PMC and refreshed weekly. Each link opens the paper itself.

Search the full literature