
Epithalon
Epitalon
Russian-language literature on pineal peptide bioregulators and telomerase activity.
Telomerase claims trace to a small number of ageing Russian studies that have never been independently replicated.
General profile
- Class
- Mitochondrial and metabolic
- Evidence
- Early or preclinical only
- Studied dose range
- 5–10 mg
- Frequency in protocols
- Daily for 10 to 20 day courses
- Route
- Subcutaneous
- Half life
- Minutes
- Reconstitution
- 2 mL bacteriostatic water per 10 mg vial
- Storage
- Refrigerated, ~30 days
Timing and cycling in the literature
Usually dosed in the bedtime window
Daily for 10 to 20 day courses
The Russian protocols run short nightly courses two or three times a year rather than continuous use, tied to pineal signalling.
Reported cycle: 3 weeks on, 20 weeks off
The Russian protocols are ten to twenty day courses repeated two or three times a year, not continuous dosing.
Watch for: Very little is documented, which is itself the thing to note.
What it conflicts with
Three separate questions, kept separate. A hard stop means the mechanisms must not run together at all and timing does not fix it. A syringe rule means the same day is fine but one barrel is not. Redundancy is not dangerous, it is paying twice to hit one target.
No named pair conflicts are on file for this compound. That is missing data, not clearance: with no compatibility data the default is separate syringes, and you still introduce one new compound at a time.
Most syringe compatibility claims here are practice and expert consensus, not peer reviewed mixing studies. A clear liquid after mixing does not prove the compounds are still active, and cloudiness, particles or gelling means discard. Active cancer, pregnancy, major cardiac care and heavy immunosuppression override every stack preference on this page.
See how Epithalon fits your week
The injection scheduler spaces doses using the clinical timing data, flags the pairs above before you draw them, and tells you why.
Model this in the injection schedulerThe studies
Human trials: Older Russian clinical reports that have not been replicated to modern standards.
Open questions: Methodology and reporting from the original studies are difficult to verify independently.
Published papers
Indexed from Europe PMC and refreshed weekly. Each link opens the paper itself.
- LCP2 mediates SUV39H1-driven cellular senescence-related chemoresistance in natural killer/T-cell lymphoma
Cell Death Dis · 2026. Zhang Y, Qian S, Yang Q, Shi Z, Dong M, Wang Z, Yang Z, Wu S, Li Z, Zhang M, Zhang X, Chen Q.
- Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Curr Pain Headache Rep · 2026 · Review. Abouelmagd ME, Aldemerdash MA, Khatatbeh AA, Osman ASA, Abbas A, Allam S, AlEdani EM, Aldemerdash A, Monteith TS.
- Therapeutic peptides in gerontology: mechanisms and applications for healthy aging
Front Aging · 2026 · Review. Mavrych V, Shypilova I, Bolgova O.
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
J Am Acad Orthop Surg Glob Res Rev · 2026 · Review. Rahman OF, Lee SJ, Seeds WA.
- A State-of-the-Art Overview on (Epi)Genomics and Personalized Skin Rejuvenating Strategies
Pharmaceutics · 2025 · Review. Tauser RG, Vasincu IM, Iacob AT, Apotrosoaei M, Profire BȘ, Lupascu FG, Chirliu OM, Profire L.
- Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
Biogerontology · 2025. Al-Dulaimi S, Thomas R, Matta S, Roberts T.
- The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy
Stem Cell Rev Rep · 2025. Gatta M, Dovizio M, Milillo C, Ruggieri AG, Sallese M, Antonucci I, Trofimov A, Khavinson V, Trofimova S, Bruno A, Ballerini P.
- Potential for Regional Resilience to Ocean Warming and Acidification Extremes: Projected Vulnerability Under Contrasting Pathways and Thresholds
Glob Chang Biol · 2025. Olson EM, John JG, Dunne JP, Stock CA, Drenkard EJ.
- Simultaneous determination of 7 thiols associated proteins in lymphoma patients'serum and cerebrospinal fluid by UHPLC-HRMS technique
Sci Rep · 2025. Ma Q, Zhang M, Fan Y, Zhao H, Wang K, Wang X, Mu Y.
- Nano-encapsulated senolytic cocktail attenuates germ cell senescence in female mice
Cell Mol Life Sci · 2025. Guan Y, Deng S, Zou X, Wei W, Li Z, Zhong J, Zhu Y, Zhang D, Ju Y, Sun QY, Zhang H.
Search the full literature
- PubMed: all indexed papers
Every indexed paper, newest first. Filter to Clinical Trial or Review in the sidebar.
- PubMed: human clinical trials only
The honest test of an evidence claim. An empty result is itself an answer.
- ClinicalTrials.gov registrations
Registered, ongoing and completed trials, including ones that never published.
- Europe PMC full text
Often surfaces open-access full text that PubMed only abstracts.