
Glutathione
The file here is mostly preclinical work plus clinic and community practice, not registrational trials.
A tripeptide antioxidant, not a signalling peptide. It oxidises quickly once reconstituted, so short storage windows matter here.
General profile
- Class
- Standalone or fussy
- Evidence
- Mixed or moderate evidence
- Studied dose range
- 100–600 mg
- Frequency in protocols
- 1–3× weekly
- Route
- Subcutaneous or intravenous
- Half life
- ~10 minutes systemically
- Reconstitution
- 5 mL bacteriostatic water per 600 mg vial
- Storage
- Refrigerated, light-protected, ~14 days
Timing and cycling in the literature
Usually dosed in the morning window
One to three times weekly
It oxidises fast once reconstituted and must be kept light-protected. Never mix it in a barrel with anything else.
Reported cycle: 8 weeks on, 4 weeks off
Clinic courses run weekly to three times weekly in blocks alongside other antioxidant support.
Watch for: It oxidises fast once reconstituted. Discard it early rather than pushing the storage window.
What it conflicts with
Three separate questions, kept separate. A hard stop means the mechanisms must not run together at all and timing does not fix it. A syringe rule means the same day is fine but one barrel is not. Redundancy is not dangerous, it is paying twice to hit one target.
- Separate syringesSame day fine, same syringe not
Glutathione + GHK-Cu
Never in one barrel
Glutathione chelates and reduces copper, so it can strip the copper that makes GHK-Cu work at all. Same day is fine. Same syringe destroys the point of the dose.
- Separate syringesSame day fine, same syringe not
Glutathione + Any copper peptide
Own line near copper compounds
Glutathione strips copper out of copper peptide complexes. Keep it away from GHK-Cu and any GHK-containing blend in the barrel.
Most syringe compatibility claims here are practice and expert consensus, not peer reviewed mixing studies. A clear liquid after mixing does not prove the compounds are still active, and cloudiness, particles or gelling means discard. Active cancer, pregnancy, major cardiac care and heavy immunosuppression override every stack preference on this page.
See how Glutathione fits your week
The injection scheduler spaces doses using the clinical timing data, flags the pairs above before you draw them, and tells you why.
Model this in the injection schedulerThe studies
Human trials: No completed human efficacy trial that establishes a dose for the use people are chasing.
Open questions: Treat published dosing as observed practice, not a validated protocol.
Published papers
Indexed from Europe PMC and refreshed weekly. Each link opens the paper itself.
- Key molecular networks underlying retinol's biphasic effects on cell proliferation through multi-omics integrative analysis using genome-scale metabolic modeling
Synth Syst Biotechnol · 2027. He P, Xiang G, Yan Y, Zhong J, Liang Y, Shu P, Lu H.
- Impact of Mild Traumatic Brain Injury (mTBI) on CYP2D6 Activity and the Restorative Effects of Melatonin and Vitamin C Supplementation
Iran J Pharm Res · 2027. Berenjian K, Gholipour Z, Khoshayand M, Sharifzadeh M, Rouini M, Hosseinzadeh Ardakani Y.
- Metabolic disruption associated with e-cigarette vaping and secondhand exposure: Urinary metabolomics evidence from a Thai population
Toxicol Rep · 2026. Tajai P, Sawatdikun S, Srisopa T, Konguthaithip G, Parinyarux P, Ditsawanon P, Charoensook P.
- Nigral biochemical and structural alterations following subacute exposure to MPTP in mice
Toxicol Rep · 2026. Henry R, Agbon AN, Musa SA, Oladele SB.
- Redox-mediated mitochondrial collapse drives intrinsic apoptotic signaling in ELT3 cells response to apigenin
Toxicol Rep · 2026. Sutjarit S, Setthawongsin C, Sakulthaew C, Meekhanon N, Ochiai K.
- Foliar application of gamma aminobutyric acid regulates sulfur metabolism and restores redox balance to improve aluminum tolerance in <i>Camelina sativa</i>
Plant Signal Behav · 2026. Murtaza G, Ahmed Z, Hassan NE, Ullah S, Rebouh NY, Alotaibi MS, Alotaibi SS, Ali S, Jafarzadeh S, Iqbal R.
- Single-cell and longitudinal transcriptomics-guided engineering of FZD1-targeting precision nanotherapy against osteosarcoma cancer stem cells
Bioact Mater · 2026. Chen Z, Li Z, Yu W, Huang H, Chen J, Jiang Y, Zhou X, Zhong L, Zhuo H, Jia Y, Li Q, Huang Y, Chen C, Zhang J, Quan Z.
- Activatable NIR-II photoacoustic probes for cancer imaging and imaging-guided therapy
Bioact Mater · 2026 · Review. Tang R, Zhang Z, Shen S, Liang G.
- Impact of chronic dietary aflatoxin B1 intake on rumen fermentation, hepatic health, oxidative stress, inflammation, and glucose-lipid metabolism in fat-tailed ewes
Vet Anim Sci · 2026. Ider N, Khalilvandi-Behroozyar H, Ahmadpour A, Farhangpajouh F, Sahebi-Ala M, Chen Y, Hosseini Ghaffari M.
- Taurochenodeoxycholic acid alleviates MPP<sup>+</sup>/MPTP-induced neurotoxicity in vitro and in vivo by suppressing ferroptosis via TGR5/cGAS/STING signaling pathway
IBRO Neurosci Rep · 2026. Wang L, Ni Y, Wang X, Ma Y, Chang Y, Chen L, Yu L, He Z, Li F.
Search the full literature
- PubMed: all indexed papers
Every indexed paper, newest first. Filter to Clinical Trial or Review in the sidebar.
- PubMed: human clinical trials only
The honest test of an evidence claim. An empty result is itself an answer.
- ClinicalTrials.gov registrations
Registered, ongoing and completed trials, including ones that never published.
- Europe PMC full text
Often surfaces open-access full text that PubMed only abstracts.