
Selank
The file here is mostly preclinical work plus clinic and community practice, not registrational trials.
Anxiolytic research analog of tuftsin. As with Semax, the clinical work is Russian-language.
General profile
- Class
- Cognitive
- Evidence
- Mixed or moderate evidence
- Studied dose range
- 250–500 mcg
- Frequency in protocols
- Daily
- Route
- Intranasal in most studies
- Half life
- Minutes, effect outlasts plasma
- Reconstitution
- Supplied as solution in most research literature
- Storage
- Refrigerated
Timing and cycling in the literature
Usually dosed in the morning window
Daily, usually intranasal
Studied for anxiolytic effect across the working day without the sedation profile of a benzodiazepine.
Reported cycle: 2 weeks on, 2 weeks off
Like Semax, the Russian clinical use is ten to fourteen day courses with gaps between them.
Watch for: Drowsiness at higher amounts and nasal irritation from intranasal use.
What it conflicts with
Three separate questions, kept separate. A hard stop means the mechanisms must not run together at all and timing does not fix it. A syringe rule means the same day is fine but one barrel is not. Redundancy is not dangerous, it is paying twice to hit one target.
- Hard stopBody level hard stop
Selank + Methylene blue and any serotonergic drug
Do not run with methylene blue or serotonergic medication
Methylene blue inhibits MAO-A. Stacked with serotonin-raising agents (SSRIs, SNRIs, MAOIs, tricyclics, tramadol, St John's Wort) the risk is serotonin syndrome. Timing does not fix this one, it is a mechanism conflict.
- Pick oneTiming
Selank + Semax
Commonly paired, still start separately
The Russian literature pairs an anxiolytic with a stimulating analog and reports no interaction. Introduce them a week apart so you know which one is doing what.
Most syringe compatibility claims here are practice and expert consensus, not peer reviewed mixing studies. A clear liquid after mixing does not prove the compounds are still active, and cloudiness, particles or gelling means discard. Active cancer, pregnancy, major cardiac care and heavy immunosuppression override every stack preference on this page.
See how Selank fits your week
The injection scheduler spaces doses using the clinical timing data, flags the pairs above before you draw them, and tells you why.
Model this in the injection schedulerThe studies
Human trials: No completed human efficacy trial that establishes a dose for the use people are chasing.
Open questions: Treat published dosing as observed practice, not a validated protocol.
Published papers
Indexed from Europe PMC and refreshed weekly. Each link opens the paper itself.
- Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives
Int J Mol Sci · 2026 · Review. Renke G, Chinellato L.
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
J Am Acad Orthop Surg Glob Res Rev · 2026 · Review. Rahman OF, Lee SJ, Seeds WA.
- "Brain doping" substances: prohibited or not in sports?
Biol Sport · 2025. Pokrywka A, Surała O, Grabowska K, Przybyła M, Granda D, Małecki A, Faiss R, Nowacka-Chmielewska M.
- Phenibutan—an Illegal Food Supplement With Psychotropic Effects and Health Risks
Dtsch Arztebl Int · 2024 · Review. Bonnet U, Scherbaum N, Schaper A, Soyka M.
- Interventional Mental Health: A Transdisciplinary Approach to Novel Psychiatric Care Delivery
Cureus · 2023 · Review. Kuo J, Block T, Nicklay M, Lau B, Green M.
- Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats
Bull Exp Biol Med · 2022. Konstantinopolsky MA, Chernyakova IV, Kolik LG.
- Development of Peptide Biopharmaceuticals in Russia
Pharmaceutics · 2022 · Review. Deigin VI, Poluektova EA, Beniashvili AG, Kozin SA, Poluektov YM.
- Antistress Action of Melanocortin Derivatives Associated with Correction of Gene Expression Patterns in the Hippocampus of Male Rats Following Acute Stress
Int J Mol Sci · 2021. Filippenkov IB, Stavchansky VV, Glazova NY, Sebentsova EA, Remizova JA, Valieva LV, Levitskaya NG, Myasoedov NF, Limborska SA, Dergunova LV.
- Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank
J Clin Pharmacol · 2021. Doyno CR, White CM.
- When an obscurity becomes trend: social-media descriptions of tianeptine use and associated atypical drug use
Am J Drug Alcohol Abuse · 2021. Smith KE, Rogers JM, Strickland JC, Epstein DH.
Search the full literature
- PubMed: all indexed papers
Every indexed paper, newest first. Filter to Clinical Trial or Review in the sidebar.
- PubMed: human clinical trials only
The honest test of an evidence claim. An empty result is itself an answer.
- ClinicalTrials.gov registrations
Registered, ongoing and completed trials, including ones that never published.
- Europe PMC full text
Often surfaces open-access full text that PubMed only abstracts.