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Research vial labelled Semax, a Cognitive peptide studied in preclinical and clinical literature

Semax

Russian nootropic with an ACTH-fragment structure and a domestic clinical literature in stroke recovery.

Most of the clinical literature is Russian-language. Translation quality varies.

General profile

Class
Cognitive
Evidence
Mixed or moderate evidence
Studied dose range
300–600 mcg
Frequency in protocols
Daily
Route
Intranasal in most studies
Half life
Minutes (metabolite active)
Reconstitution
Supplied as solution in most research literature
Storage
Refrigerated

Timing and cycling in the literature

Usually dosed in the morning window

Daily, usually intranasal

Stimulating and alerting in the published work. Late-day dosing is a common cause of self-reported insomnia.

Reported cycle: 2 weeks on, 2 weeks off

The Russian clinical use is short courses of ten to fourteen days, repeated with gaps.

Watch for: Irritability, insomnia when dosed late, and blood pressure if you already run high.

What it conflicts with

Three separate questions, kept separate. A hard stop means the mechanisms must not run together at all and timing does not fix it. A syringe rule means the same day is fine but one barrel is not. Redundancy is not dangerous, it is paying twice to hit one target.

  • Hard stopBody level hard stop

    Semax + Methylene blue and any serotonergic drug

    Do not run with methylene blue or serotonergic medication

    Methylene blue inhibits MAO-A. Stacked with serotonin-raising agents (SSRIs, SNRIs, MAOIs, tricyclics, tramadol, St John's Wort) the risk is serotonin syndrome. Timing does not fix this one, it is a mechanism conflict.

  • Separate syringesTiming

    Semax + DSIP

    Opposite ends of the day, minimum 8 hours

    One is studied for sedation and slow-wave sleep, the other for alertness. Co-administering them cancels the observable effect of both and tells you nothing.

  • Pick oneRedundant, pick one

    Semax + Adamax

    Same target hit twice

    Adamax is a modified Semax, not a second mechanism.

  • Pick oneRedundant, pick one

    Semax + P-21

    Same target hit twice

    Overlapping Semax-family signalling. Introduce one, hold it, then judge.

  • Pick oneTiming

    Semax + Selank

    Commonly paired, still start separately

    The Russian literature pairs an anxiolytic with a stimulating analog and reports no interaction. Introduce them a week apart so you know which one is doing what.

Most syringe compatibility claims here are practice and expert consensus, not peer reviewed mixing studies. A clear liquid after mixing does not prove the compounds are still active, and cloudiness, particles or gelling means discard. Active cancer, pregnancy, major cardiac care and heavy immunosuppression override every stack preference on this page.

See how Semax fits your week

The injection scheduler spaces doses using the clinical timing data, flags the pairs above before you draw them, and tells you why.

Model this in the injection scheduler

The studies

Human trials: Russian trials, largely unreplicated in Western literature.

Open questions: Reporting standards make independent appraisal difficult.

Published papers

Indexed from Europe PMC and refreshed weekly. Each link opens the paper itself.

Search the full literature